Oncogenic G12D mutation alters local conformations and dynamics of K-Ras
نویسندگان
چکیده
منابع مشابه
The Effects of Oncogenic G12d Mutation on K-ras Structure, Conformation and Dynamics
K-Ras is the most frequently mutated protein in human tumors. Activating K-Ras mutations drive cancer initiation, progression and drug resistance, directly leading to nearly a million deaths per year. To understand the mechanisms by which mutations alter K-Ras function, we need to understand their effects on protein dynamics. However, despite decades of research, how oncogenic mutations in K-Ra...
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Genetic mutations in K-Ras, an oncogene belonging to the Ras protein superfamily, are present in number of cancers, including over 90% of pancreatic and 50% of colorectal cancers. The mutated or oncogenic form of the K-Ras GTPase is perpetually locked in the GTP-bound active conformation, thereby inducing extreme and rapid cell proliferation as well as decreasing cell sensitivity to suspension-...
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Mouse models of cancer represent powerful tools for analysing the role of genetic alterations in carcinogenesis. Using a mouse model that allows tamoxifen-inducible somatic activation (by Cre-mediated recombination) of oncogenic K-ras(G12D) in a wide range of tissues, we observed hyperplasia of squamous epithelium located in moist or frequently abraded mucosa, with the most dramatic effects in ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-48029-z